Dynamic surface tension effects during airway reopening

Author

Gaver, D.P., III ; Brennan, R. ; Zimmer, M.

Author_Institution

Dept. of Biomed. Eng., Tulane Univ., New Orleans, LA, USA

Volume

2

fYear

2002

fDate

2002

Firstpage

1491

Abstract

Pulmonary airways can become occluded by lining fluid that impairs gas-exchange with the alveoli. To reopen these airways, a bubble of air must separate the airway walls, which can introduce large stresses on epithelial cells. In this paper we present modeling studies that aim to identify stress magnitudes on these cells, and the use of pulsatile ventilation strategies to open collapsed airways with minimal damage.

Keywords

biomechanics; bubbles; cellular biophysics; lung; physiological models; pneumodynamics; pulsatile flow; surface tension; surfactants; air bubble; airway reopening; airway walls; alveoli; collapsed airways; dynamic surface tension effects; epithelial cells; gas-exchange; large stresses; lining fluid; minimal damage; pulmonary airways; pulsatile ventilation strategies; stress magnitudes; surfactant transport; ventilator-induced lung injury; Frequency; Hydrodynamics; Lungs; Pediatrics; Proteins; Steady-state; Stress; Surface tension; Tissue damage; Ventilation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1106500

Filename

1106500