Title :
Ionic current model of a hypoglossal motoneuron
Author :
Purvis, L.K. ; Wilson, C.G. ; Butera, R.J.
Author_Institution :
Dept. of Electr. Eng., Georgia Inst. of Technol., Atlanta, GA, USA
Abstract :
We have developed a Hodgkin-Huxley type neuron model of a respiratory hypoglossal motoneuron (HM). The model consists of a single compartment containing a repertoire of ionic currents. The model reproduces several characteristics of HMs and accurately replicates the neuron´s response to various pharmacological experiments. We also have studied the model´s response to synaptic input, and its ability to integrate and transmit the inspiratory rhythm produced by the transverse slice preparation. The model provides explanations to how the cell produces the afterdepolarization and afterhyperpolarization seen in the HM action potential.
Keywords :
biocontrol; bioelectric potentials; biomembrane transport; brain models; neurophysiology; pneumodynamics; Hodgkin-Huxley type neuron model; action potential; afterdepolarization; afterhyperpolarization; inspiratory rhythm; ionic current model; pharmacological experiments; respiratory hypoglossal motoneuron; rhythmic activity; single compartment; synaptic input; transverse slice preparation; Biomedical engineering; Biomedical measurements; Brain modeling; Calcium; Low voltage; Neurons; Neurophysiology; Nuclear measurements; Pacemakers; Rhythm;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1106507
