An experiment-based model of oxygen transport in capillary networks under normal and septic conditions

Author

Goldman, D. ; Bateman, R.M. ; Ellis, C.G.

Author_Institution

Dept. of Math. Sci., New Jersey Inst. of Technol., NJ, USA

Volume

2

fYear

2002

fDate

2002

Firstpage

1517

Abstract

A previously described computational model (Ellis et al., 2002, and Goldman and Popel, 2000) for oxygen transport in capillary networks of the hamster cheek pouch retractor muscle is adapted to study the rat extensor digitorum longus muscle. Biophysical parameters from the literature are combined with experimental measurements to construct a model of capillary network structure and oxygen transport from blood to tissue. We describe how experimental values are related to model parameters, and how numerical simulations can be used to determine the effects of sepsis on oxygen transport heterogeneity and the development of localized tissue hypoxia.

Keywords

biotransport; blood vessels; cardiovascular system; haemorheology; mass transfer; muscle; oxygen; partial differential equations; physiological models; O₂; biophysical parameters; biotransport; blood; blood vessels; capillary networks; cardiovascular system; computational model; experiment-based model; hamster cheek pouch retractor muscle; localized tissue hypoxia; mathematical model; normal conditions; numerical simulations; oxygen transport; physiological models; rat extensor digitorum longus muscle; septic conditions; spatial heterogeneity; Blood flow; Boundary conditions; Computational modeling; Computer networks; Data flow computing; Data mining; Equations; Intelligent networks; Mathematical model; Oxygen;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1106514

Filename

1106514