Title :
Microbead immunoassay dipstick system (MIDS)
Author :
Colston, Bill ; Visuri, Steve ; Mcbride, M. ; Rao, Rupa ; Richards, Jim ; Chuang, Frank ; Chang, John ; Carlson, James ; Derlet, Robert
Author_Institution :
Lawrence Livermore Nat. Lab., CA, USA
Abstract :
Summary form only given. We have developed a prototype system for reducing Luminex based immunoassay technology to a portable, customizable platform that can perform multiplexed assays on location - independent of clinical laboratory support. In principle, this device can be used to test for any biomolecular interaction in which strong binding occurs, including receptor-ligand coupling, enzyme-substrate binding, antibody-antigen interactions, and nucleic acid (DNA) hybridization reactions. Since an overwhelming majority of clinical laboratory tests are based on antibody-antigen interactions, however, we have focusing our initial efforts on multiplexed immunoassay detection.
Keywords :
biochemistry; biological specimen preparation; biological techniques; molecular biophysics; patient diagnosis; DNA hybridization reactions; Luminex based immunoassay technology; antibody-antigen interactions; biomolecular interaction; clinical applications; disposable sample preparation; enzyme-substrate binding; microbead immunoassay dipstick system; multiplexed assays; multiplexed immunoassay detection; pathogen specific optically encoded microbead templates; portable customizable platform; receptor-ligand coupling; strong binding; Contamination; Fungi; Immune system; Instruments; Laboratories; Microorganisms; Pathogens; Protocols; Testing; Viruses (medical);
Conference_Titel :
Lasers and Electro-Optics Society, 2002. LEOS 2002. The 15th Annual Meeting of the IEEE
Print_ISBN :
0-7803-7500-9
DOI :
10.1109/LEOS.2002.1134080
