The influence of nanosecond pulsed field on a double-shelled ellipsoid cell

When cells are exposed to very short and high strength electric pulses, they will deform from spherical shape to ellipsoidal shape, and these effects may occur on cellular and organelles. Because of their potential clinical applications, selective effects on organelles are of particular interest. In this work, we use the finite element method to investigate the influence of nanosecond pulsed field on a double-shell ellipsoidal cell. The corresponding transmembrane potential (TMP) and pore density are examined to analyze the response of cells to such a short pulse field. Our active model demonstrates that for the prolate double-shelled cell, the TMP and pore density of the nuclear membrane exceed that on the cell membrane. Our calculation may be useful to guide electroporation experiments.