Title :
Action potential heterogeneity assists frequency entrainment in the intact cardiac pacemaker
Author :
Cloherty, S.L. ; Lovell, N.H. ; Dokos, S. ; Celler, B.G.
Author_Institution :
Graduate Sch. of Biomed. Eng., New South Wales Univ., Sydney, NSW, Australia
Abstract :
The role of cellular heterogeneity in frequency entrainment of the primary cardiac pacemaker has been investigated using an idealized two dimensional model of the rabbit sinoatrial node and surrounding atrial tissue. Simulation results are presented which support the hypothesis, that regional variation in action potential waveshape contributes to pacemaker synchronization in-vivo.
Keywords :
bioelectric potentials; cardiology; cellular biophysics; neurophysiology; action potential heterogeneity; action potential waveshape variation; cardiac electrophysiology; frequency entrainment assistance; idealized two dimensional model; pacemaker synchronization in-vivo; primary cardiac pacemaker; rabbit sinoatrial node; regional variation; simulation results; surrounding atrial tissue; Australia; Biomedical engineering; Biomembranes; Conductivity; Finite element methods; Frequency synchronization; Laboratories; Pacemakers; Rabbits; Storage area networks;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1134476
