Action potential heterogeneity assists frequency entrainment in the intact cardiac pacemaker

Author

Cloherty, S.L. ; Lovell, N.H. ; Dokos, S. ; Celler, B.G.

Author_Institution

Graduate Sch. of Biomed. Eng., New South Wales Univ., Sydney, NSW, Australia

Volume

1

fYear

2002

fDate

2002

Firstpage

248

Abstract

The role of cellular heterogeneity in frequency entrainment of the primary cardiac pacemaker has been investigated using an idealized two dimensional model of the rabbit sinoatrial node and surrounding atrial tissue. Simulation results are presented which support the hypothesis, that regional variation in action potential waveshape contributes to pacemaker synchronization in-vivo.

Keywords

bioelectric potentials; cardiology; cellular biophysics; neurophysiology; action potential heterogeneity; action potential waveshape variation; cardiac electrophysiology; frequency entrainment assistance; idealized two dimensional model; pacemaker synchronization in-vivo; primary cardiac pacemaker; rabbit sinoatrial node; regional variation; simulation results; surrounding atrial tissue; Australia; Biomedical engineering; Biomembranes; Conductivity; Finite element methods; Frequency synchronization; Laboratories; Pacemakers; Rabbits; Storage area networks;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1134476

Filename

1134476