Title :
Modeling the cyclic relationship between myoplasmic [Ca2+] and isovolumic LVP in guinea-pig intact hearts
Author :
Rhodes, Samhita S. ; Audi, Said ; Stowe, David F. ; Camara, Amadou K. ; Kevin, Leo ; Ropella, Kristina
Author_Institution :
Dept. of Biomed. Eng., Marquette Univ., Milwaukee, WI, USA
Abstract :
We modified a previously developed mathematical model to interpret the cyclic relationship between myoplasmic [Ca2+] and left ventricular pressure (LVP) in the guinea-pig intact heart and evaluated the effects of ischemia/reperfusion (IR) injury on the model parameters. Parameters descriptive of the rate of [Ca2+] binding to troponin C (TnC) protein on the actin myofilament decreased following IR injury indicating a reduction in myofilament sensitivity to myoplasmic [Ca2+]. In addition, the model predicts diastolic contracture following IR injury by a reduced rate of myofilament cross-bridges dissociation. Changes in model parameters reflect underlying pathological changes in myocardial contractility, relaxation and cytosolic Ca2+ handling ability, following IR injury.
Keywords :
biochemistry; bioelectric phenomena; biomembrane transport; calcium; cardiology; haemodynamics; muscle; physiological models; Ca; cardiac electrophysiology; cardiac muscle cells; cyclic relationship modeling; cytosolic Ca2+ handling ability; diastolic contracture; ischemia/reperfusion injury; isovolumic LVP; left ventricular pressure; model parameters; myocardial contractility relaxation; myofilament cross-bridges dissociation rate; myoplasmic [Ca2+]; troponin C protein; underlying pathological changes; Calcium; Cardiology; Fluorescence; Heart; Injuries; Ischemic pain; Mathematical model; Muscles; Pathology; Physiology;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1134478
