A biodynamical regulatory model of the human T-cell system

Author

Brandt, Michael E. ; Wang, Guanyu ; Krueger, Gerhard R F ; Buja, L. Maximilian

Author_Institution

Health Sci. Center-SHIS, Univ. of Texas, Houston, TX, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

254

Abstract

We describe a biodynamical regulatory model of the human T-cell system based on a set of coupled ordinary differential equations. The model incorporates subsystems representing bone marrow, thymus and peripheral (mature T-cell) compartments and allows simulations of viral challenges to the system which lead to various disorders such as leukemia-like syndromes, AIDS, and herpes infections. We provide two examples, one of normative data across the lifespan and the other acute human herpes virus (HHV-6) infection.

Keywords

blood; cancer; cellular biophysics; differential equations; physiological models; predator-prey systems; AIDS; HHV-6; acute human herpes virus infection; biodynamical regulatory model; bone marrow; coupled ordinary differential equations set; human T-cell system; leukemia-like syndromes; lifespan; mature T-cells; normative data; peripheral compartment; thymus; viral challenges simulation; Acquired immune deficiency syndrome; Biological system modeling; Blood; Bones; Cells (biology); Differential equations; Feedback; Humans; Immune system; Mathematical model;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1134479

Filename

1134479