Title :
Using direct force measurements to determine the mechanism of neural cell adhesion molecule (NCAM) function
Author :
Leckband, D. ; Johnson, C. ; Roberts, R. ; Fujimoto, I. ; Anderson, B. ; Rutishauser, U.
Author_Institution :
Dept. of Chem. Eng., Illinois Univ., Urbana, IL, USA
Abstract :
The molecular mechanism of homophilic adhesion between neural cell adhesion molecules (NCAM) was investigated by direct force measurements. The force-distance profiles demonstrated that multiple domains are involved in adhesion. In addition, the effect of polysialylation on the interprotein forces provided insights into the molecular mechanism by which posttranslational modification regulates NCAM function.
Keywords :
adhesion; biomechanics; force measurement; molecular biophysics; neurophysiology; proteins; cell-cell signaling; direct force measurements; force-distance profiles; homophilic adhesion; homophilic interactions; identical proteins on opposing cells; molecular mechanism; multiple domains; neural cell adhesion molecules; neuronal cell adhesion proteins; polysialylation effect; posttranslational modification; Adhesives; Biophysics; Cancer; Cells (biology); Chemical engineering; Chemistry; Computational biology; Force measurement; Lipidomics; Protein engineering;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1134524
