Title :
Culturing smooth muscle cells on modified PDMS substrates
Author :
Li, Meng ; Ai, H. ; Mills, D.K. ; Lvov, Y.M. ; Gale, Bruce K. ; McShane, M.J.
Author_Institution :
Inst. for Micromanufacturing, Louisiana Tech. Univ., Ruston, LA, USA
Abstract :
Polydimethylsiloxane (PDMS) is a popular biocompatible material to be used in cell culture area. However, due to its hydrophobic surface property, cells cannot grow on its bare surface very well. In this paper, electrostatic layer-by-layer (LbL) self-assembly technology was used to coat thin films of hydrophilic and biocompatible materials, poly(dimethyldiallylammonium chloride) (PDDA), poly(styrene sulfonate) (PSS), and gelatin, on the surface of cell culture substrate to increase the growth and alignment of smooth muscle cells (SMCs).
Keywords :
biomedical materials; cellular biophysics; muscle; polymers; biocompatible materials; cell growth increase; gelatin; hydrophilic materials; layer-by-layer self-assembly; microfabrication; modified PDMS substrates; poly(dimethyldiallylammonium chloride); poly(styrene sulfonate); smooth muscle cells culturing; thin films coating; tissue engineering; Assembly; Biological materials; Biomedical engineering; Electrostatics; Microchannel; Muscles; Nonhomogeneous media; Optical microscopy; Self-assembly; Surface treatment;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1136858
