Static compression inhibits matrix protein gene expression and increases collagenase gene expression in the meniscus

Author

Upton, M.L. ; Chen, Jiann-Jong ; Guilak, F. ; Setton, L.A.

Author_Institution

Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

438

Abstract

The biological response of the meniscus to static compression was quantified as changes in gene expression levels for relevant extracellular matrix proteins. Decreased mRNA levels for decorin and type I collagen were observed, as well as increased mRNA levels for the matrix metalloproteinase MMP-1. These findings demonstrate that the response of the meniscus to mechanical stimuli may be regulated in part at the transcriptional level.

Keywords

biological tissues; biomechanics; genetics; orthopaedics; proteins; biologically active tissue; decreased mRNA levels; increased mRNA levels; joint stability; knee; load distribution; matrix protein gene expression inhibition; mechanical stimuli; orthopedic biomechanics; static compression; transcriptional level; type I collagen; Biomedical engineering; Compressive stress; Fluorescence; Gene expression; Joints; Knee; Orthopedic surgery; Protein engineering; RNA; Tensile stress;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1136884

Filename

1136884