Title :
Tailored drug release profiles from bioerodible polyanhydride microspheres
Author :
Kipper, Mad ; Determan, Amy ; Narasimhan, Balaji
Author_Institution :
Dept. of Chem. Eng., Iowa State Univ., Ames, IA, USA
Abstract :
The fabrication, morphological characterization, and drug release kinetics from microspheres of three bioerodible polyanhydrides, poly[1,6-bis(p-carboxyphenoxy)hexane] (poly(CPH)), poly(sebacic anhydride) (poly(SA)), and the copolymer poly(CPH-co-SA) 50:50 (CPH:SA 50:50) are reported. Tailored release profiles of a burst followed by zero-order release are obtained by appropriately combining the microspheres in ´cocktails.´.
Keywords :
drug delivery systems; polymer blends; bioerodible polyanhydride microspheres; burst; drug release characteristics; microsphere characterization; microsphere cocktails; morphological characteristics; poly(sebacic anhydride); poly[1,6-bis(p-carboxyphenoxy)hexane]; solvent removal; tailored drug release profiles; zero-order release; Degradation; Drug delivery; Fabrication; Kinetic theory; Morphology; Nuclear magnetic resonance; Polymers; Scanning electron microscopy; Solvents; Spectroscopy;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1136915
