Title :
Fluid shear-induced membrane fluctuations measured by laser dark field microscopy
Author :
Haidekker, M.A. ; Stevens, H.Y. ; Frangos, J.A.
Author_Institution :
Dept. of Bioeng., California Univ., San Diego, La Jolla, CA, USA
Abstract :
The mechanism of mechanochemical signal transduction remains to be elucidated. There is mounting evidence that mechanochemical transduction in response to fluid shear stress occurs at the cell membrane. We previously demonstrated that fluid shear stress increases membrane free volume. Here we present evidence that fluid shear amplifies thermal fluctuations in the cell membrane. These results present further support of the membrane free volume theory of mechanochemical transduction.
Keywords :
biological techniques; biomembranes; biothermics; cellular biophysics; haemorheology; measurement by laser beam; optical microscopy; cell membrane; fluid shear-induced membrane fluctuations; laser dark field microscopy; mechanochemical transduction; mechanotransduction; membrane free volume increase; membrane thermal fluctuations; shear stress; Biomedical engineering; Biomembranes; Cells (biology); Fluctuations; Light scattering; Measurement by laser beam; Microscopy; Proteins; Surface morphology; Thermal stresses;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1136962
