Title :
Surface chemistry modulates integrin binding, focal adhesion assembly and matrix mineralization
Author :
Keselowsky, B.G. ; Collard, D.M. ; Garcia, A.J.
Author_Institution :
Coulter Sch. of Biomed. Eng., Georgia Inst. of Technol., Atlanta, GA, USA
Abstract :
Integrin-mediated adhesion to the extracellular matrix protein fibronectin (FN) triggers signals that control proliferation, gene expression and matrix mineralization in osteoblasts. We have engineered model surfaces presenting well-defined chemistries that modulate FN adsorption/conformation, integrin binding and focal adhesion assembly. These changes in adhesive interactions modulate osteoblast-specific gene expression and matrix mineralization.
Keywords :
adhesion; biochemistry; bone; cellular biophysics; genetics; proteins; surface chemistry; extracellular matrix protein fibronectin; focal adhesion assembly; integrin binding; integrin-mediated adhesion; matrix mineralization; osteoblast-specific gene expression modulation; proliferation control; well-defined chemistries; Adhesives; Assembly; Biomedical engineering; Bones; Chemistry; Gene expression; Immune system; Mineralization; Orthopedic surgery; Tissue engineering;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1136973
