Dynamic loading increases strength of tissue-engineered chordae tendineae

Author

Shi, Y. ; Vesely, I.

Author_Institution

Dept. of Biomed. Eng., Cleveland Clinic Found., OH, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

833

Abstract

We have used directed collagen gel shrinkage to fabricate tissue-engineered mitral valve chordae tendineae. These constructs have a microstructure similar to that of native chordae - a dense collagen core and an elastin sheath surrounding it. We designed a dynamic loading system to stretch the constructs in vitro to improve their mechanical properties. At 5 weeks of culture, dynamically loaded constructs have a 120% increase in failure strength relative to statically loaded constructs.

Keywords

biological tissues; biomechanics; cardiology; mechanical strength; patient treatment; proteins; shrinkage; 5 w; collagen fibers; dense collagen core; dynamically loaded constructs; elastin sheath; failure strength; mechanical properties improvement; microstructure; mitral valve dysfunction correction; mitral valve repair; statically loaded constructs; tissue biomechanics; tissue-engineered chordae tendineae; Biological materials; Biomedical engineering; Bioreactors; Connective tissue; Extracellular; In vitro; Mechanical factors; Microstructure; Morphology; Valves;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1137099

Filename

1137099