Title :
Computational analysis of calcium transients in the intact rat heart; model identification
Author :
van Riel, N.A.W. ; van der Vusse, G.J.
Author_Institution :
Dept. of Electr. Eng., Eindhoven Univ. of Technol., Netherlands
Abstract :
The sarcoplasmic calcium transients determine the contraction strength during the cardiac cycle. A computational model has been derived that can be uniquely identified based on the available time series data of the free calcium concentration in the sarcoplasm. The model assesses the quantitatively most important processes in calcium handling in the intact heart at an integral system level. The in vivo kinetic parameters of cardiac calcium handling have been analyzed.
Keywords :
biomembrane transport; calcium; cardiology; cellular biophysics; nonlinear systems; physiological models; proteins; Ca+; cardiac calcium handling; cardiac cycle; computational analysis; contraction strength; free calcium concentration; in vivo kinetic parameters; intact rat heart; model identification; sarcoplasmic calcium transients; time series data; Biological system modeling; Biomembranes; Calcium; Extracellular; Fluorescence; Heart; Kinetic theory; Myocardium; Strontium; Transient analysis;
Conference_Titel :
Decision and Control, 2002, Proceedings of the 41st IEEE Conference on
Print_ISBN :
0-7803-7516-5
DOI :
10.1109/CDC.2002.1184218
