Condition of supralinear amplification in pairing action potentials with EPSPS

Author

Urakubo, Hidetoshi ; Watanabe, Masataka

Author_Institution

Dept. of Quantum Eng. & Syst. Sci., Univ. of Tokyo, Bunkyo, Japan

Volume

1

fYear

2002

fDate

18-22 Nov. 2002

Firstpage

25

Abstract

We simulate pairing backpropagating action potentials (APs) with excitatory postsynaptic potentials (EPSPs) in a hippocampal CA1 model neuron, and make clear the synaptic-site dependence of the supralinear amplification, which is considered as the origin of LTP in spike-timing dependent plasticity (STDP). Pairing APs with EPSPs at randomly determined synaptic sites reveals that the supralinear amplification needs modest APs with strong EPSPs, and the sites are restricted in apical middle dendrites and basal distal dendrites with small diameters. We also discuss the importance of this restriction in hippocampal information processing.

Keywords

backpropagation; bioelectric potentials; neural nets; EPSPS; action potential pairing; apical middle dendrites; backpropagating action potentials; basal distal dendrites; excitatory postsynaptic potentials; hippocampal CA1 model neuron; hippocampal information processing; spike-timing dependent plasticity; supralinear amplification; synaptic-site dependence; Arithmetic; Biomembranes; Capacitance; Information processing; Kinetic theory; Morphology; Neurons; Shape; Systems engineering and theory; Timing;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Information Processing, 2002. ICONIP '02. Proceedings of the 9th International Conference on

Print_ISBN

981-04-7524-1

Type

conf

DOI

10.1109/ICONIP.2002.1202124

Filename

1202124