mGluRs effect needs to reproduce spike timing dependent plasticity from postsynaptic calcium concentration

Author

Urakubo, Hidetoshi ; Watanabe, Manabu

Author_Institution

Dept. of Quantum Eng. & Syst. Sci., Univ. of Tokyo, Bunkyo, Japan

Volume

3

fYear

2002

fDate

18-22 Nov. 2002

Firstpage

1490

Abstract

In this study, we inquire the generation mechanism of the spike-timing dependent synaptic plasticity by computer simulation. Postsynaptic Ca²⁺ concentration in a spine determines synaptic plasticity. We examine the spike timing dependence of Ca²⁺ concentration with a multi-compartment model of a hippocampal CA1 pyramidal cell. Consequently, only the Ca²⁺ concentration does not account for STDP, but the Ca²⁺ concentration filtered by mGluR-activation reproduces STDP timing window.

Keywords

bioelectric phenomena; neural nets; neurophysiology; physiological models; Ca; hippocampal CA 1 pyramidal cell; long-term depression; mGluR-activation; multiple compartment model; postsynaptic calcium concentration; spike-timing dependent plasticity; spike-timing dependent synaptic plasticity; Biological neural networks; Biomembranes; Calcium; Computer simulation; Image reconstruction; Neurons; Organizing; Protocols; Systems engineering and theory; Timing;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Information Processing, 2002. ICONIP '02. Proceedings of the 9th International Conference on

Print_ISBN

981-04-7524-1

Type

conf

DOI

10.1109/ICONIP.2002.1202868

Filename

1202868