mGluRs effect needs to reproduce spike timing dependent plasticity from postsynaptic calcium concentration

In this study, we inquire the generation mechanism of the spike-timing dependent synaptic plasticity by computer simulation. Postsynaptic Ca²⁺ concentration in a spine determines synaptic plasticity. We examine the spike timing dependence of Ca²⁺ concentration with a multi-compartment model of a hippocampal CA1 pyramidal cell. Consequently, only the Ca²⁺ concentration does not account for STDP, but the Ca²⁺ concentration filtered by mGluR-activation reproduces STDP timing window.