Title :
Advanced biochip: principle and applications in medical diagnostics and pathogen detection
Author :
Vo-Dinh, T. ; Griffin, G.D. ; Wintenberg, A.L. ; Stokes, D.L. ; Mobley, J. ; Askari, M. ; Maples, R.
Author_Institution :
Oak Ridge Nat. Lab., TN, USA
Abstract :
An important factor in medical diagnostics is rapid, selective, and sensitive detection of biochemical substances (proteins, metabolites, nucleic acids), biological species or living systems (bacteria, virus or related components) at trace levels in biological samples (e.g., tissues, blood and other bodily fluids). This manuscript provides an overview of the operating principle and application of an integrated multi-functional biochip based on integrated circuit complementary metal oxide semiconductor (CMOS) sensor array for use in medical diagnostics and pathogen detection. The usefulness and potential of the biochip as a rapid diagnostic tool at the physician´s office and as a practical, inexpensive screening tool for pathogens under field conditions are discussed.
Keywords :
CMOS integrated circuits; biochemistry; biomedical electronics; biomedical transducers; biosensors; diseases; integrated optoelectronics; mixed analogue-digital integrated circuits; patient diagnosis; CMOS sensor array; bacteria; biochip; biological species detection; biosensor microchips; blood; bodily fluids; inexpensive screening tool; infectious diseases; integrated CMOS photodetectors; integrated multi-functional biochip; living systems; medical diagnostics; metabolites; nucleic acids; pathogen detection; proteins; rapid diagnostic tool; sensitive biochemical substance detection; tissues; trace level detection; virus; Application specific integrated circuits; Biological tissues; Biosensors; Blood; CMOS integrated circuits; Medical diagnosis; Microorganisms; Pathogens; Proteins; Sensor arrays;
Conference_Titel :
Circuits and Systems, 2003. ISCAS '03. Proceedings of the 2003 International Symposium on
Print_ISBN :
0-7803-7761-3
DOI :
10.1109/ISCAS.2003.1205096
