Parallel iterative reconstruction methods for structure determination of biological specimens by electron microscopy

This work addresses the application of blob-based series expansion methods in structure determination of macromolecules from the perspective of computational speed and convergence rate. This work explores the use of traditional series expansion methods, such as algebraic reconstruction techniques, as well as other very recently developed methods: such as averaging sequential strings or component averaging methods characterized by a really fast convergence, achieving least-squares solutions in a few iterations.