Title :
Real-time two-photon fluorescence microscopy of blood flow dynamics following photothrombotic stroke in rat neocortex
Author :
Schaffer, Chris B. ; Ebner, Ford F. ; Nishimura, Nozomi ; Friedman, Beth ; Tsai, Phibert S. ; Schroeder, Lee F. ; Lyden, Patrick D. ; Kleinfeld, David
Author_Institution :
Dept. of Phys., California Univ., La Jolla, CA, USA
Abstract :
We use two-photon microscopy to observe changes in blood flow after localized photothrombotic clotting of individual blood vessels in rat neocortex. We find that flow reverses direction downstream from clotted arterioles, thereby maintaining tissue perfusion.
Keywords :
bio-optics; biomedical optical imaging; blood flow measurement; blood vessels; brain; diseases; fluorescence; haemorheology; optical microscopy; two-photon processes; blood flow; blood vessels; clotted arterioles; photothrombotic clotting; photothrombotic stroke; rat neocortex; real-time fluorescence microscopy; tissue perfusion; two-photon fluorescence microscopy; Animals; Blood flow; Blood vessels; Coagulation; Fluorescence; Ischemic pain; Microscopy; Physics; Rats; Red blood cells;
Conference_Titel :
Lasers and Electro-Optics Society, 2003. LEOS 2003. The 16th Annual Meeting of the IEEE
Print_ISBN :
0-7803-7888-1
DOI :
10.1109/LEOS.2003.1251760
