Neuromodulation for Brain Disorders: Challenges and Opportunities

Author

Johnson, M.D. ; Lim, H.H. ; Netoff, Theoden I. ; Connolly, A.T. ; Johnson, Nadiyah ; Roy, Anirban ; Holt, A. ; Lim, Kelvin O. ; Carey, J.R. ; Vitek, J.L. ; Bin He

Author_Institution

Dept. of Biomed. Eng., Univ. of Minnesota, Minneapolis, MN, USA

Volume

60

Issue

3

fYear

2013

fDate

Mar-13

Firstpage

610

Lastpage

624

Abstract

The field of neuromodulation encompasses a wide spectrum of interventional technologies that modify pathological activity within the nervous system to achieve a therapeutic effect. Therapies including deep brain stimulation, intracranial cortical stimulation, transcranial direct current stimulation, and transcranial magnetic stimulation have all shown promising results across a range of neurological and neuropsychiatric disorders. While the mechanisms of therapeutic action are invariably different among these approaches, there are several fundamental neuroengineering challenges that are commonly applicable to improving neuromodulation efficacy. This paper reviews the state-of-the-art of neuromodulation for brain disorders and discusses the challenges and opportunities available for clinicians and researchers interested in advancing neuromodulation therapies.

Keywords

bioelectric phenomena; biomedical engineering; brain; medical disorders; neurophysiology; patient treatment; transcranial magnetic stimulation; brain disorders; deep brain stimulation; fundamental neuroengineering; interventional technology; intracranial cortical stimulation; nervous system; neurological disorders; neuromodulation; neuromodulation efficacy; neuromodulation therapy; neuropsychiatric disorders; pathological activity; therapeutic action; therapeutic effect; transcranial direct current stimulation; transcranial magnetic stimulation; Educational institutions; Electrodes; Neurons; Parkinson´s disease; Satellite broadcasting; Surgery; Deep brain stimulation (DBS); intracranial cortical stimulation (ICS); neuroengineering; neuromodulation; transcranial direct current stimulation (tDCS); transcranial magnetic stimulation (TMS); Animals; Biomedical Research; Brain Diseases; Deep Brain Stimulation; Humans; Transcranial Magnetic Stimulation;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/TBME.2013.2244890

Filename

6428623