Light scattering "fingerprints" of initial pre-dysplastic events in colon carcinogenesis

Author

Kim, Young L. ; Liu, Yang ; Wali, Ramesh K. ; Roy, Hemant K. ; Goldberg, Michael J. ; Kromine, Alexei K. ; Chen, Kun ; Backman, Vadim

Author_Institution

Dept. of Biomed. Eng., Northwestern Univ., Evanston, IL, USA

Volume

2

fYear

2003

fDate

17-21 Sept. 2003

Firstpage

1076

Abstract

We report detection of slight alterations of tissue micro-architecture by recording multidimensional data characterizing tissue light scattering. In the animal studies, we show that these light scattering "fingerprints" change dramatically even in the earliest pre-dysplastic stages of carcinogenesis, much earlier than currently known histological, molecular, or genetic markers.

Keywords

bio-optics; biological tissues; biomedical measurement; cancer; genetics; light scattering; molecular biophysics; patient diagnosis; spectroscopy; animal study; cancer diagnosis; colon carcinogenesis; elastic light scattering; fingerprints; genetic marker; histological marker; molecular marker; polarization light scattering spectroscopy; pre-dysplastic event; slight alteration; tissue light scattering; tissue micro-architecture; Animals; Cancer; Charge coupled devices; Colon; Fingerprint recognition; Instruments; Light scattering; Mie scattering; Optical polarization; Optical scattering;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7789-3

Type

conf

DOI

10.1109/IEMBS.2003.1279432

Filename

1279432