Title :
Light scattering "fingerprints" of initial pre-dysplastic events in colon carcinogenesis
Author :
Kim, Young L. ; Liu, Yang ; Wali, Ramesh K. ; Roy, Hemant K. ; Goldberg, Michael J. ; Kromine, Alexei K. ; Chen, Kun ; Backman, Vadim
Author_Institution :
Dept. of Biomed. Eng., Northwestern Univ., Evanston, IL, USA
Abstract :
We report detection of slight alterations of tissue micro-architecture by recording multidimensional data characterizing tissue light scattering. In the animal studies, we show that these light scattering "fingerprints" change dramatically even in the earliest pre-dysplastic stages of carcinogenesis, much earlier than currently known histological, molecular, or genetic markers.
Keywords :
bio-optics; biological tissues; biomedical measurement; cancer; genetics; light scattering; molecular biophysics; patient diagnosis; spectroscopy; animal study; cancer diagnosis; colon carcinogenesis; elastic light scattering; fingerprints; genetic marker; histological marker; molecular marker; polarization light scattering spectroscopy; pre-dysplastic event; slight alteration; tissue light scattering; tissue micro-architecture; Animals; Cancer; Charge coupled devices; Colon; Fingerprint recognition; Instruments; Light scattering; Mie scattering; Optical polarization; Optical scattering;
Conference_Titel :
Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE
Print_ISBN :
0-7803-7789-3
DOI :
10.1109/IEMBS.2003.1279432
