A gradient model of the rabbit sinoatrial node

Author

Cloherty, S.L. ; Dokos, S. ; Lovell, N.H.

Author_Institution

Graduate Sch. of Biomedical Eng., New South Wales Univ., Sydney, NSW, Australia

Volume

1

fYear

2003

fDate

17-21 Sept. 2003

Firstpage

24

Abstract

We have formulated a gradient model of the rabbit sinoatrial node based on cell-specific ionic models of electrical activity from its central and peripheral regions. The gradient model exhibits a smooth transition in action potential characteristics such as maximum diastolic potential, overshoot potential, upstroke velocity, action potential duration and cycle length, and is suitable for developing higher dimensional models of the right atrium. Spontaneous pacemaker activity is simulated in a one-dimensional monodomain model of the sinoatrial node and adjoining atrial tissue.

Keywords

bioelectric potentials; cellular biophysics; electrocardiography; physiological models; action potential characteristics; action potential duration; adjoining atrial tissue; cell-specific ionic models; cycle length; electrical activity; gradient model; maximum diastolic potential; one-dimensional monodomain model; overshoot potential; rabbit sinoatrial node; spontaneous pacemaker activity; upstroke velocity; Australia; Biomedical engineering; Biomembranes; Equations; Heart beat; Interpolation; Least squares methods; Pacemakers; Rabbits; Storage area networks;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7789-3

Type

conf

DOI

10.1109/IEMBS.2003.1279487

Filename

1279487