Nonlinear analysis of failed ventricular defibrillation

Author

Simonotto, Jennifer D. ; Furman, Michael D. ; Ditto, William L. ; Spano, Mark L. ; Liu, Gang ; Kavanagh, Katherine M.

Author_Institution

Dept. of Biomed. Eng., Florida Univ., Gainesville, FL, USA

Volume

1

fYear

2003

fDate

17-21 Sept. 2003

Firstpage

196

Abstract

A high-speed video camera and voltage-sensitive dyes were used to acquire high resolution (80 × 80 pixels) and high-speed (1 ms/frame) optical signals of ventricular fibrillation in a Langendorff-perfused porcine heart. The resulting spatiotemporal dynamics were recorded before and after the application of a defibrillation shock in order to study the mechanism of defibrillation failure. We created time space cubes and calculated nonlinear synchronization index measures to qualify the evolution of different types of activity on the heart surface (focal, reentry). We observed changes with time in all types of analysis, thus establishing these techniques as viable methods for detecting defibrillation failure before reentry reestablishes itself.

Keywords

bioelectric potentials; biomedical optical imaging; cardiology; defibrillators; medical image processing; patient diagnosis; 80 pixel; Langendorff-perfused porcine heart; defibrillation failure; defibrillation shock; nonlinear synchronization index; optical signals; spatiotemporal dynamics; ventricular defibrillation; video camera; voltage-sensitive dyes; Cameras; Defibrillation; Failure analysis; Fibrillation; Heart; High speed optical techniques; Nonlinear optics; Optical recording; Signal resolution; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7789-3

Type

conf

DOI

10.1109/IEMBS.2003.1279566

Filename

1279566