DocumentCode :
406454
Title :
A computational model of upper airway collapsibility
Author :
Huang, Yaqi ; Malhotra, Atul ; White, David P.
Author_Institution :
Dept. of Medicine, Brigham & Women´´s Hosp., MA, USA
Volume :
1
fYear :
2003
fDate :
17-21 Sept. 2003
Abstract :
A computational model is being developed to investigate pharyngeal collapsibility, pertinent to obstructive sleep apnea. The geometrical structure of the pharyngeal airway is constructed from mid-sagittal plane MR images from normal subjects. The genioglossal muscle activation is simulated by a pressure and state dependent contraction module. This model establishes a direct connection between the contractile forces and the measured electromyogram signals at various upper airway conditions and effectively avoids the difficulty in determining the muscle shortening velocity at complex pharyngeal conditions when modeling muscle contractions. Using the finite element method, we simulate the genioglossal muscle activation behaviors and mimic air flow, tissue deformation and collapse under negative pharyngeal pressures. Using our model, we simulate mandibular advancement and show it to change the collapsibility markedly. A 1-cm advancement decreases pharyngeal closing pressure from -13 to about -20 cmH2O. The present study shows that a realistic computational model can simulate pharyngeal collapsibility and potentially improve the treatment of sleep apnea.
Keywords :
biomechanics; biomedical MRI; diseases; electromyography; finite element analysis; neuromuscular stimulation; physiological models; pneumodynamics; pressure control; sleep; air flow; contractile forces; electromyogram signals; finite element method; genioglossal muscle activation; mandibular advancement; mid-sagittal plane MR images; muscle contractions; muscle shortening velocity; negative pharyngeal pressures; obstructive sleep apnea; pharyngeal airway; pharyngeal closing pressure; pharyngeal collapsibility; state dependent contraction module; tissue deformation; upper airway collapsibility; Animals; Biomedical imaging; Computational modeling; Finite element methods; Force measurement; Hospitals; Humans; Medical simulation; Muscles; Sleep apnea;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE
ISSN :
1094-687X
Print_ISBN :
0-7803-7789-3
Type :
conf
DOI :
10.1109/IEMBS.2003.1279656
Filename :
1279656
Link To Document :
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