• DocumentCode
    406561
  • Title

    Extraction of action potential waveform from summed neural signals

  • Author

    Silva, R. ; Zook, J. ; Gaumond, R.

  • Author_Institution
    Pennsylvania State Univ., University Park, PA, USA
  • Volume
    2
  • fYear
    2003
  • fDate
    17-21 Sept. 2003
  • Firstpage
    1917
  • Abstract
    We consider the problem of interpreting the signal recorded from an electrode, which sums currents from a large number of neurons responding asynchronously to an applied stimulus. We use a markov chain numerical simulation to establish conditions under which the action potential waveform can be extracted from the autocorrelation of the summed signal, by means of the Levinson algorithm. We tested the efficacy of the algorithm in recovering the signal for two different action potential (AP) waveforms under different test conditions. We conclude that our system is both capable of recovering the average AP and detecting changes in its morphology.
  • Keywords
    bioelectric potentials; neurophysiology; numerical analysis; physiological models; Levinson algorithm; action potential waveform; field potential; multiple neuron; summed neural signal; Conductivity; Data mining; Electrodes; Extracellular; Morphology; Neurons; Numerical simulation; Shape; Testing; Voltage;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE
  • ISSN
    1094-687X
  • Print_ISBN
    0-7803-7789-3
  • Type

    conf

  • DOI
    10.1109/IEMBS.2003.1279800
  • Filename
    1279800