Title :
Viscoelastic behavior of rat cortex in response to micro-scalp-volume fluid injections
Author :
Nunamaker, E.A. ; Rathnasingham, R. ; Kipke, D.R.
Author_Institution :
Dept. of Biomed. Eng., Michigan Univ., Ann Arbor, MI, USA
Abstract :
The characterization of the performance of microfluidic devices in the brain is crucial for reliable in-vivo drug delivery applications. Understanding the properties of brain tissue surrounding the microfluidic device and the mechanical response to a bolus delivery is important for optimizing the delivery capabilities. This study investigates the viscoelastic response of brain tissue to a micro-scale fluid volume. It was determined that significant tissue pressure changes and tissue relaxation time constants could be measured accurately and were found to correlate with the displacement volume used for injection. This is an important finding in developing and optimizing MEMS based in-vivo fluid delivery systems.
Keywords :
biological tissues; biomechanics; biomimetics; brain; drug delivery systems; microfluidics; neurophysiology; prosthetics; viscoelasticity; BioMEMS; bolus delivery; brain tissue; drug delivery; in-vivo drug delivery application; mechanical response; micro-scale fluid volume; micro-scalp-volume fluid injection; microfluidic device; neuroprosthesis; rat cortex; tissue pressure change; tissue relaxation time constant; viscoelastic behavior; Brain; Displacement measurement; Drug delivery; Elasticity; Mechanical factors; Microfluidics; Pressure measurement; Viscosity; Volume measurement; Volume relaxation;
Conference_Titel :
Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE
Print_ISBN :
0-7803-7789-3
DOI :
10.1109/IEMBS.2003.1279823
