Viscoelastic behavior of rat cortex in response to micro-scalp-volume fluid injections

Author

Nunamaker, E.A. ; Rathnasingham, R. ; Kipke, D.R.

Author_Institution

Dept. of Biomed. Eng., Michigan Univ., Ann Arbor, MI, USA

Volume

2

fYear

2003

fDate

17-21 Sept. 2003

Firstpage

1948

Abstract

The characterization of the performance of microfluidic devices in the brain is crucial for reliable in-vivo drug delivery applications. Understanding the properties of brain tissue surrounding the microfluidic device and the mechanical response to a bolus delivery is important for optimizing the delivery capabilities. This study investigates the viscoelastic response of brain tissue to a micro-scale fluid volume. It was determined that significant tissue pressure changes and tissue relaxation time constants could be measured accurately and were found to correlate with the displacement volume used for injection. This is an important finding in developing and optimizing MEMS based in-vivo fluid delivery systems.

Keywords

biological tissues; biomechanics; biomimetics; brain; drug delivery systems; microfluidics; neurophysiology; prosthetics; viscoelasticity; BioMEMS; bolus delivery; brain tissue; drug delivery; in-vivo drug delivery application; mechanical response; micro-scale fluid volume; micro-scalp-volume fluid injection; microfluidic device; neuroprosthesis; rat cortex; tissue pressure change; tissue relaxation time constant; viscoelastic behavior; Brain; Displacement measurement; Drug delivery; Elasticity; Mechanical factors; Microfluidics; Pressure measurement; Viscosity; Volume measurement; Volume relaxation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7789-3

Type

conf

DOI

10.1109/IEMBS.2003.1279823

Filename

1279823