DocumentCode :
406647
Title :
Blood volume measurements by videodensitometric analysis of ultrasound-contrast-agent dilution curves
Author :
Mischi, M. ; Kalker, A.A.C.M. ; Korsten, H.H.M.
Author_Institution :
Technical Univ. Eindhoven, Netherlands
Volume :
1
fYear :
2003
fDate :
17-21 Sept. 2003
Firstpage :
971
Abstract :
The assessment of blood volumes provides useful information on the circulatory system. Especially the intra-thoracic blood volume (ITBV), which is measured by invasive trans-pulmonary indicator dilution techniques, is related to the symmetry of the cardiac efficiency. This paper presents a new non-invasive indicator dilution technique for blood volume measurements. The indicator is an ultrasound contrast agent, which is detected by videodensitometric analysis of echocardiographic videos. Different indicator dilution curves (IDC) are measured simultaneously in different sites. The mean transit time (MTT) of the contrast between the measurement sites is multiplied by the blood flow to determine the blood volumes. The local density random walk model is used to fit and interpret the IDC. The MTT is easily derived from the fitted model. A specific fast and accurate least-square fitting algorithm is adopted. The in-vitro results show very accurate volume measurements with standard deviation smaller than 4.8% of the volume. The in-vivo application of the system in humans shows promising results too.
Keywords :
blood flow measurement; curve fitting; densitometry; echocardiography; least squares approximations; medical image processing; ITBV; blood volume measurements; echocardiographic videos; intrathoracic blood volume; invasive transpulmonary indicator dilution; least-square fitting algorithm; local density random walk model; mean transit time; ultrasound-contrast-agent dilution curves; videodensitometric analysis; Blood flow; Circulatory system; Fluid flow measurement; In vitro; Measurement standards; Time measurement; Ultrasonic imaging; Ultrasonic variables measurement; Videos; Volume measurement;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE
ISSN :
1094-687X
Print_ISBN :
0-7803-7789-3
Type :
conf
DOI :
10.1109/IEMBS.2003.1279929
Filename :
1279929
Link To Document :
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