Magnetoencephalographic analysis of alpha frequency light entrainment of brain activity in dementia patients

Author

Tamura, Toshiyo ; Imoto, Toshiro Fuj ; Masuda, Yasushi ; Kohdabashi, Atushi ; Higashi, Yuji ; Shimooki, Susumu

Author_Institution

Nara Inst. of Adv. Sci. & Technol., Fujimoto Hayasuzu Hosp., Nara, Japan

Volume

3

fYear

2003

fDate

17-21 Sept. 2003

Firstpage

2103

Abstract

We used magnetoencephalography (MEG) to analyze the power spectrum and light entrainment in patients with symptoms of Alzheimer´s disease ( AD; n = 5 ) or cerebrovascular dementia (CV; n = 1 ). A 160-channel MEG and an electroencephalogram (EEG) were recorded simultaneously in each patient while they were at rest with their eyes open and stimulated by pulses of light ( 8-10.5 Hz at 0.5-Hz intervals). A spectral analysis was carried out and the amplitude of each frequency determined. The results show that the AD patients did not entrain at some frequencies, whereas the CV patients exhibited entrainment of the alpha wave, although the amplitude was smaller than in normal subjects.

Keywords

biological effects of optical radiation; diseases; electroencephalography; magnetoencephalography; 8 to 10.5 Hz; Alzheimer disease; EEG; MEG; alpha frequency light entrainment; brain activity; cerebrovascular dementia; dementia patients; electroencephalogram; light stimulation; magnetoencephalographic analysis; Alzheimer´s disease; Brain; Dementia; Electroencephalography; Frequency; Hospitals; Magnetic analysis; Magnetic resonance imaging; Magnetoencephalography; Sensor arrays;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7789-3

Type

conf

DOI

10.1109/IEMBS.2003.1280152

Filename

1280152