Title :
Multi-pulse generator for electroporation
Author :
Ping, Wu ; Jiali, Bao ; Hong, Wang ; Huiping, Wang
Author_Institution :
Coll. of Med., Zhejiang Univ., Hangzhou, China
Abstract :
A multi-pulse generator provides a tool for the research of electroporation for transdermal drug delivery. The multi-pulse generator with which capacitor charges and discharges can generate a series pulse that is controlled by a pulse controller, and output of a voltage source in the apparatus is risen from DC 12 V of power supply to DC 400 V by a converter. And it is recorded some graphs of pulse of which applies to skin using Ag-AgCl electrode placed to same side of stratum corneum with the storage capacitance of 2.2 μF, 22 μF, 68 μF and 100 μF, respectively. Results show that when truncation coefficient is less than 1/5, the complete exponential decay pulse can be acquired, and skin resistance is 3.57±0.66 KΩ. Hence, the truncation coefficient is restricted by transdermal energy and pulse protocol. If parallel resistance and storage capacitance are optimally designed, it can be obtained that the highest energy efficiency of the power supply and the lowest truncation coefficient of pulse.
Keywords :
bioelectric phenomena; biomedical electrodes; biomembrane transport; drug delivery systems; skin; 100 muF; 12 to 400 V; 2.2 muF; 22 muF; 3.57 kohm; 68 muF; Ag-AgCl; Ag-AgCl electrode; capacitor charges; capacitor discharges; electroporation; exponential decay pulse; multipulse generator; pulse controller; pulse protocol; stratum corneum; transdermal drug delivery; transdermal energy; Capacitance; Capacitors; DC generators; Drug delivery; Fault location; Power generation; Pulse generation; Pulsed power supplies; Skin; Voltage control;
Conference_Titel :
Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE
Print_ISBN :
0-7803-7789-3
DOI :
10.1109/IEMBS.2003.1280542
