DocumentCode
406998
Title
Transdermal drug delivery: a comparative analysis of skin impedance models and parameters
Author
Coston, Anthony F. ; Li, John K J
Author_Institution
Instrum. & Electron., Ethicon Inc., Somerville, MA, USA
Volume
3
fYear
2003
fDate
17-21 Sept. 2003
Firstpage
2982
Abstract
Variability in skin impedance can significantly influence the effectiveness of transdermal drug delivery. In order to optimize drug delivery, skin impedance frequency response must be considered. Several electrical models for skin impedance and a comparative analysis of different model parameters are presented in an attempt to identify critical parameters for an efficient drug delivery through iontophoresis. It was concluded that skin resistance and capacitance, as well as the mode of stimulation are important considerations in optimal transdermal drug delivery.
Keywords
bioelectric phenomena; drug delivery systems; electric impedance measurement; physiological models; skin; electrical models; iontophoresis; skin capacitance; skin impedance; skin resistance; transdermal drug delivery; Capacitance; Circuits; Drug delivery; Electric resistance; Frequency; Immune system; Impedance; Polarization; Pulse measurements; Skin;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE
ISSN
1094-687X
Print_ISBN
0-7803-7789-3
Type
conf
DOI
10.1109/IEMBS.2003.1280545
Filename
1280545
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