Title :
In-vivo targeted gene transfer to skin by nanosecond pulsed laser-induced stress waves
Author :
Ogura, M. ; Obara, M.
Author_Institution :
Dept. of Electron. & Electr. Eng., Keio Univ., Yokohama, Japan
Abstract :
We demonstrated that laser-induced stress waves enhanced transfection efficiency in rat´s skin in vivo by a factor of 120 over the naked DNA injection. Site-and tissue specific gene expressions were observed.
Keywords :
DNA; genetics; high-speed optical techniques; molecular biophysics; skin; DNA injection; enhanced transfection efficiency; in-vivo targeted gene transfer; nanosecond pulsed laser; skin; specific gene expression; stress wave; Chemical lasers; DNA; Educational institutions; Fiber lasers; Gene therapy; Laser theory; Optical fibers; Optical pulses; Skin; Stress;
Conference_Titel :
Lasers and Electro-Optics, 2003. CLEO '03. Conference on
Conference_Location :
Baltimore, MD, USA
Print_ISBN :
1-55752-748-2
