Title :
Plasma Medical Science for Cancer Therapy: Toward Cancer Therapy Using Nonthermal Atmospheric Pressure Plasma
Author :
Tanaka, H. ; Mizuno, M. ; Ishikawa, K. ; Takeda, K. ; Nakamura, K. ; Utsumi, F. ; Kajiyama, H. ; Kano, H. ; Okazaki, Y. ; Toyokuni, S. ; Maruyama, S. ; Kikkawa, F. ; Hori, M.
Author_Institution :
Plasma Med. Sci. Global Innovation Center, Nagoya Univ., Nagoya, Japan
Abstract :
We have been developing novel ultrahigh density atmospheric pressure plasma sources and succeeded in the selective killing ovarian cancer cells against normal ones. Furthermore, we have found out the plasma-activated medium (PAM) also killed glioblastoma brain tumor cells selectively against normal ones and the chemical products in the PAM have long lifetime healing effects. To clarify the mechanism, interactions of plasma with the organism and the medium where the organism belongs were investigated on the viewpoint of intracellular molecular mechanism.
Keywords :
brain; cancer; cellular biophysics; molecular biophysics; patient treatment; plasma applications; plasma sources; tumours; PAM; cancer therapy; chemical products; glioblastoma brain tumor cells; intracellular molecular mechanism; long lifetime healing effects; nonthermal atmospheric pressure plasma; organism; ovarian cancer cells; plasma interactions; plasma medical science; plasma-activated medium; pressure 1 atm; ultrahigh density atmospheric pressure plasma sources; Atmospheric-pressure plasmas; Cancer; Medical treatment; Plasma sources; Tumors; Cancer therapy; non-thermal atmospheric pressure plasma; plasma-activated medium;
Journal_Title :
Plasma Science, IEEE Transactions on
DOI :
10.1109/TPS.2014.2353659
