Plasma Medical Science for Cancer Therapy: Toward Cancer Therapy Using Nonthermal Atmospheric Pressure Plasma

Author

Tanaka, H. ; Mizuno, M. ; Ishikawa, K. ; Takeda, K. ; Nakamura, K. ; Utsumi, F. ; Kajiyama, H. ; Kano, H. ; Okazaki, Y. ; Toyokuni, S. ; Maruyama, S. ; Kikkawa, F. ; Hori, M.

Author_Institution

Plasma Med. Sci. Global Innovation Center, Nagoya Univ., Nagoya, Japan

Volume

42

Issue

12

fYear

2014

fDate

Dec. 2014

Firstpage

3760

Lastpage

3764

Abstract

We have been developing novel ultrahigh density atmospheric pressure plasma sources and succeeded in the selective killing ovarian cancer cells against normal ones. Furthermore, we have found out the plasma-activated medium (PAM) also killed glioblastoma brain tumor cells selectively against normal ones and the chemical products in the PAM have long lifetime healing effects. To clarify the mechanism, interactions of plasma with the organism and the medium where the organism belongs were investigated on the viewpoint of intracellular molecular mechanism.

Keywords

brain; cancer; cellular biophysics; molecular biophysics; patient treatment; plasma applications; plasma sources; tumours; PAM; cancer therapy; chemical products; glioblastoma brain tumor cells; intracellular molecular mechanism; long lifetime healing effects; nonthermal atmospheric pressure plasma; organism; ovarian cancer cells; plasma interactions; plasma medical science; plasma-activated medium; pressure 1 atm; ultrahigh density atmospheric pressure plasma sources; Atmospheric-pressure plasmas; Cancer; Medical treatment; Plasma sources; Tumors; Cancer therapy; non-thermal atmospheric pressure plasma; plasma-activated medium;

fLanguage

English

Journal_Title

Plasma Science, IEEE Transactions on

Publisher

ieee

ISSN

0093-3813

Type

jour

DOI

10.1109/TPS.2014.2353659

Filename

6955848