Physiologically-based minimal model of agitation-sedation dynamics

Author

Rudge, A.D. ; Chase, J.G. ; Shaw, G.M. ; Lee, D.

Author_Institution

Dept. of Mechanical Eng., Canterbury Univ., Christchurch, New Zealand

Volume

1

fYear

2004

fDate

1-5 Sept. 2004

Firstpage

774

Lastpage

777

Abstract

Agitation-sedation cycling in critically ill patients, characterized by oscillations between states of agitation and over-sedation, damages patient health and increases length of stay and cost. The model presented captures the essential dynamics of the agitation-sedation system, is physiologically representative, and is validated by accurately simulating patient response for 37 critical care patients. The model provides a platform to develop and test controllers that offer the potential of improved agitation management.

Keywords

patient treatment; physiological models; agitation-sedation dynamics; critical care patients; improved agitation management; patient health; physiologically-based minimal model; Costs; Drugs; Hospitals; Mathematics; Mechanical engineering; Medical treatment; Nonlinear dynamical systems; Protocols; Statistics; Testing; Agitation; Dynamic modeling; Non-linear dynamics; Physiological models; Sedation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE

Conference_Location

San Francisco, CA

Print_ISBN

0-7803-8439-3

Type

conf

DOI

10.1109/IEMBS.2004.1403273

Filename

1403273