Estimation of ethanol infusion profile to produce specified BrAC time course using physiologically-based pharmacokinetic (PBPK) models

Author

Plawecki, M.H. ; Decarlo, R.A. ; Ramchandani, V.A. ; O´Connor, S.

Author_Institution

Dept. of Biomedical Eng., Purdue Univ., West Lafayette, IN, USA

Volume

1

fYear

2004

fDate

1-5 Sept. 2004

Firstpage

778

Lastpage

781

Abstract

A procedure for estimating the alcohol infusion profile required to produce a specific breath alcohol concentration (BrAC) time course using a PBPK model is described. Model parameter values are predicted from linear relationships to readily measurable physical characteristics or morphometrics. An algorithm to optimize this transformation, based upon recorded clinical experimental data, is provided. A substantial improvement in all error statistics, in relation to the original transform was obtained.

Keywords

drugs; estimation theory; physiological models; alcohol infusion profile; ethanol infusion profile estimation; morphometrics; physiologically-based pharmacokinetic models; specific breath alcohol concentration time course; Absorption; Alcoholic beverages; Alcoholism; Biomedical engineering; Biomedical measurements; Clamps; Drugs; Ethanol; History; Physiology; alcohol; breath alcohol concentration time course; least squares approximation; morphometrics; optimization; parameter identification; pharmacokinetics; physiologically-based pharmacokinetic model;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE

Conference_Location

San Francisco, CA

Print_ISBN

0-7803-8439-3

Type

conf

DOI

10.1109/IEMBS.2004.1403274

Filename

1403274