Ion channels - estimation and control at macroscopic and nano scales

Author

Krishnamurthy, Vikram

Author_Institution

Dept. of Electr. & Comput. Eng., British Columbia Univ., Canada

Volume

1

fYear

2004

fDate

20-23 July 2004

Firstpage

42

Abstract

All electrical activities in the nervous system, including communications between cells and the influence of hormones and drugs on cell function, are regulated by membrane ion channels. Therefore understanding their mechanisms at a molecular level is a fundamental problem in biology. This paper shows how ideas in hidden Markov model signal processing, stochastic control and stochastic optimization can be used to understand the operation of ion channels at both a macroscopic and nano scales.

Keywords

biocontrol; bioelectric phenomena; biomembrane transport; hidden Markov models; optimisation; physiological models; stochastic processes; stochastic systems; biology; electrical activities; gating problem; hidden Markov model signal processing; ion channel control; ion channel estimation; macroscopic scale; membrane ion channel; molecular level; nanoscale; nervous system; permeation problem; stochastic control; stochastic optimization; Biochemistry; Biomedical signal processing; Biomembranes; Cells (biology); Communication system control; Drugs; Hidden Markov models; Nervous system; Process control; Stochastic processes;

fLanguage

English

Publisher

ieee

Conference_Titel

Control Conference, 2004. 5th Asian

Conference_Location

Melbourne, Victoria, Australia

Print_ISBN

0-7803-8873-9

Type

conf

Filename

1425934