Title :
Optimal control in a model of dendritic cell transfection cancer immunotherapy
Author :
Castiglione, F. ; Piccoli, B.
Author_Institution :
Ist. Applicazioni del Calcolo, Consiglio Nazionale delle Ricerche, Rome, Italy
Abstract :
We build a population dynamics model of the competition among immune system cells and a generic tumor cells. Then, we apply the theory of optimal control to find the optimal schedule of injection of autologous dendritic cells used as immunotherapeutic agent.
Keywords :
cancer; cellular biophysics; optimal control; optimisation; physiological models; tumours; dendritic cell transfection cancer immunotherapy; generic tumor cells; immune system cells; optimal control; population dynamics model; Biological system modeling; Biology computing; Cancer; Cells (biology); Immune system; Mathematical model; Neoplasms; Optimal control; Optimal scheduling; Tumors;
Conference_Titel :
Decision and Control, 2004. CDC. 43rd IEEE Conference on
Conference_Location :
Nassau
Print_ISBN :
0-7803-8682-5
DOI :
10.1109/CDC.2004.1428694
