• DocumentCode
    434622
  • Title

    Gains and optimal design in signaling pathways

  • Author

    Chaves, Madalena ; Sontag, Eduardo D. ; Dinerstein, Robert J.

  • Author_Institution
    Dept. of Mathematics, Rutgers Univ., New Brunswick, NJ, USA
  • Volume
    1
  • fYear
    2004
  • fDate
    17-17 Dec. 2004
  • Firstpage
    596
  • Abstract
    Signal amplification and other input-to-output properties of signaling cascades are characterized by the H∞ gain in the case of linear systems, or by the L2 induced norm in the nonlinear case. The effect of the length of the cascade on the output signal is examined. In particular, for a fixed gain, there is an optimal length that generates "sharp" outputs (signals that simultaneously exhibit short duration and high amplitude).
  • Keywords
    amplification; biochemistry; bioelectric phenomena; biomembrane transport; enzymes; molecular biophysics; physiological models; cellular signal transduction; linear systems; optimal design; signal amplification; signaling cascade; signaling pathways; Character generation; Drugs; Gene expression; Informatics; Linear systems; Mathematics; Proteins; Signal design; Signal generators; Transfer functions;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Decision and Control, 2004. CDC. 43rd IEEE Conference on
  • Conference_Location
    Nassau
  • ISSN
    0191-2216
  • Print_ISBN
    0-7803-8682-5
  • Type

    conf

  • DOI
    10.1109/CDC.2004.1428697
  • Filename
    1428697
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=434622