DocumentCode :
438127
Title :
Dual low profile detector heads for a restraint free small animal SPECT imaging system
Author :
Weisenberger, A.G. ; Baba, J.S. ; Kross, B. ; Gleason, S.S. ; Goddard, J. ; Majewski, S. ; Meikle, S.R. ; Paulus, M.J. ; Pomper, M.G. ; Popov, V. ; Smith, M.F. ; Welch, B.L. ; Wojcik, R.
Author_Institution :
Jefferson Lab., Newport News, VA, USA
Volume :
4
fYear :
2004
fDate :
16-22 Oct. 2004
Firstpage :
2456
Abstract :
A small animal single photon emission computed tomography (SPECT) system has been developed for acquiring in vivo images of the biodistribution of radiopharmaceuticals in unrestrained, awake small animal models. This system uses two dedicated gamma-ray cameras and an infrared based animal position tracking system mounted on a rotational gantry with an infrared transparent mouse burrow in the center. The original implementation of this system had two compact gamma cameras with an active area of 5 cm×5 cm. Two new gamma camera detector heads with active areas of 10 cm×20 cm have been built, tested and installed in the SPECT gantry to replace the 5 cm×5 cm detectors. The new gamma cameras are based on pixellated NaI(Tl) crystal scintillator arrays, coupled to arrays of compact position-sensitive photomultiplier tubes (PSPMT) to achieve high spatial resolution in a compact, low profile device. A novel cost-effective readout is utilized. The two detector heads are based on a 4×8 array of Hamamatsu R8520-C12 position sensitive photomultiplier tubes. Each PSPMT array is coupled to a pixellated 10 cm×20 cm NaI(Tl) scintillator crystal array with individual crystal elements of 2 mm×2 mm×15 mm in size and a septum of 0.25 mm between elements. Samples of phantom and animal studies are presented. The detectors are capable of imaging 125I and 99mTc labeled radiopharmaceuticals in live mice.
Keywords :
cellular biophysics; gamma-ray apparatus; iodine; phantoms; pharmaceuticals; photomultipliers; position sensitive particle detectors; radioactive tracers; single photon emission computed tomography; solid scintillation detectors; technetium; 10 cm; 15 mm; 2 mm; 20 cm; 125I labeled radiopharmaceuticals; 99mTc labeled radiopharmaceuticals; Hamamatsu R8520-C12 position sensitive photomultiplier tubes; I; NaI(Tl) scintillator crystal array; PSPMT; Tc; biodistribution; cost-effective readout; dual low profile detector heads; gamma-ray cameras; high spatial resolution; in vivo images; infrared based animal position tracking system; infrared transparent mouse burrow; live mice; phantom; pixellated NaI(Tl) crystal scintillator arrays; radiopharmaceuticals; restraint free small animal SPECT imaging system; rotational gantry; single photon emission computed tomography; Animals; Cameras; Gamma ray detection; Gamma ray detectors; Head; In vivo; Mice; Optical imaging; Photomultipliers; Single photon emission computed tomography;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Nuclear Science Symposium Conference Record, 2004 IEEE
ISSN :
1082-3654
Print_ISBN :
0-7803-8700-7
Type :
conf
DOI :
10.1109/NSSMIC.2004.1462753
Filename :
1462753
Link To Document :
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