Transmission imaging with axially overlapping cone-beams

We have shown that cone-beam transmission imaging of medium-energy photons that penetrate the parallel-hole collimators can be used to rapidly estimate attenuation maps for use in reconstruction of cardiac SPECT images. Such a transmission imaging geometry offers the advantages of eliminating the need to mechanically move the point-sources during imaging, and minimizes cross-talk between emission and transmission imaging. The axial extent over which artifact-free attenuation maps can be reconstructed is limited by the cone-beam geometry and source collimation. We investigated irradiation of a single head by multiple point-sources such that their asymmetric cone-beam fields overlap in the axial direction as a method of extending the axial coverage of the patient. This study reports on testing of a penalized-likelihood algorithm for transmission reconstruction of overlapping cone-beams. This algorithm was evaluated through MCAT simulations and applied to transmission measurements of an anthropomorphic phantom. The experimental work consisted of performing a series of flood and transmission measurements on the anthropomorphic phantom with shifted axial locations of point-sources. We summed the projection data from individual measurements to simulate the projection data for a multiple point-source system. With the proposed penalized-Iikelihood algorithm, the full axial extent (20.5 cm) of the anthropomorphic phantom was reconstructed for the overlapping cone-beam geometry with 2 point-sources per camera head.