Statistical 3D image reconstruction for the RatCAP PET tomograph using a physically accurate, Monte Carlo based system matrix

Author

Shokouhi, S. ; Vaska, P. ; Southekal, S. ; Schlyer, D. ; Purschke, M. ; Dzordzhadze, V. ; Woody, C. ; Stoll, S. ; Alexoff, D.L. ; Rubins, D. ; Villanueva, A. ; Krishnamoorthy, S.

Author_Institution

Biomed. Eng. Dept., State Univ. of New York, Stony Brook, NY, USA

Volume

6

fYear

2004

fDate

16-22 Oct. 2004

Firstpage

3901

Abstract

This work describes a fully 3D statistical image reconstruction for the RatCAP (Rat Conscious Animal PET) using a Monte Carlo based system matrix. The RatCAP consists of 12 Iutetium oxyorthosilicate (LSO)-avalanche photodiode (APD) detector blocks arranged in a ring of 41.2 mm diameter. Due to the small ring diameter and low number of total lines of response (LORs), the size of a complete system matrix is small in comparison to a typical small animal scanner. This allows incorporation of an accurate, RatCAP-specific physical model with the inclusion of crystal penetration, Compton scattering in both rat´s brain and detector, attenuation and the realistic event positioning errors. The trade off between the statistical accuracy and the matrix computational time as it relates to the accuracy of image reconstruction will also be discussed.

Keywords

Compton effect; Monte Carlo methods; avalanche photodiodes; brain; image reconstruction; image scanners; medical image processing; positron emission tomography; solid scintillation detectors; 3D image reconstruction; 41.2 mm; Compton scattering; LSO-avalanche photodiode detector block; Monte Carlo system matrix; RatCAP PET tomograph; RatCAP-specific physical model; crystal penetration; lutetium oxyorthosilicate; matrix computational time; rat brain; rat conscious animal PET; realistic event positioning errors; small animal scanner; statistical accuracy; Animals; Attenuation; Brain modeling; Detectors; Event detection; Image reconstruction; Monte Carlo methods; Photodiodes; Positron emission tomography; Scattering;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2004 IEEE

ISSN

1082-3654

Print_ISBN

0-7803-8700-7

Electronic_ISBN

1082-3654

Type

conf

DOI

10.1109/NSSMIC.2004.1466731

Filename

1466731