Title :
Modeling and incorporation of system response functions in 3D whole body PET
Author :
Alessio, Adam M. ; Kinahan, Paul E. ; Lewellen, Thomas K.
Author_Institution :
Med. Center, Washington Univ., Seattle, WA, USA
Abstract :
Appropriate application of spatially variant system models can correct for degraded resolution response and mispositioning errors. This work explores the detector blurring component of the system model for a whole body PET system and extends this factor into a more general system response function to account for other system non-idealities such as the influence of FORE rebinning. We model the system response function as a 3 dimensional function that blurs in the radial and axial dimension and is spatially variant in radial location. This function is derived from Monte Carlo simulations and incorporates inter-crystal scatter, crystal penetration, and the blurring due to FORE rebinning. The improved system model is applied in a modified OSEM algorithm to reconstruct FORE rebinned, fully 3D PET data into images with improved resolution and quantitative accuracy.
Keywords :
Monte Carlo methods; image reconstruction; image resolution; medical image processing; optimisation; positron emission tomography; 3 dimensional function; 3D whole body PET; FORE rebinned reconstruction; FORE rebinning; Monte Carlo simulations; crystal penetration; degraded resolution response; detector blurring component; image resolution; inter-crystal scatter; mispositioning errors; modified OSEM algorithm; quantitative accuracy; spatially variant system model; system modeling; system response functions; Biological system modeling; Degradation; Detectors; Error correction; Image reconstruction; Image resolution; Photonic crystals; Positron emission tomography; Spatial resolution; Whole-body PET;
Conference_Titel :
Nuclear Science Symposium Conference Record, 2004 IEEE
Print_ISBN :
0-7803-8700-7
Electronic_ISBN :
1082-3654
DOI :
10.1109/NSSMIC.2004.1466752
