Modeling and incorporation of system response functions in 3D whole body PET

Author

Alessio, Adam M. ; Kinahan, Paul E. ; Lewellen, Thomas K.

Author_Institution

Med. Center, Washington Univ., Seattle, WA, USA

Volume

6

fYear

2004

fDate

16-22 Oct. 2004

Firstpage

3992

Abstract

Appropriate application of spatially variant system models can correct for degraded resolution response and mispositioning errors. This work explores the detector blurring component of the system model for a whole body PET system and extends this factor into a more general system response function to account for other system non-idealities such as the influence of FORE rebinning. We model the system response function as a 3 dimensional function that blurs in the radial and axial dimension and is spatially variant in radial location. This function is derived from Monte Carlo simulations and incorporates inter-crystal scatter, crystal penetration, and the blurring due to FORE rebinning. The improved system model is applied in a modified OSEM algorithm to reconstruct FORE rebinned, fully 3D PET data into images with improved resolution and quantitative accuracy.

Keywords

Monte Carlo methods; image reconstruction; image resolution; medical image processing; optimisation; positron emission tomography; 3 dimensional function; 3D whole body PET; FORE rebinned reconstruction; FORE rebinning; Monte Carlo simulations; crystal penetration; degraded resolution response; detector blurring component; image resolution; inter-crystal scatter; mispositioning errors; modified OSEM algorithm; quantitative accuracy; spatially variant system model; system modeling; system response functions; Biological system modeling; Degradation; Detectors; Error correction; Image reconstruction; Image resolution; Photonic crystals; Positron emission tomography; Spatial resolution; Whole-body PET;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2004 IEEE

ISSN

1082-3654

Print_ISBN

0-7803-8700-7

Electronic_ISBN

1082-3654

Type

conf

DOI

10.1109/NSSMIC.2004.1466752

Filename

1466752