Multimodal functional and morphological nonrigid image registration

The aim of this work is to present the registration of two different and complementary imaging modalities of the human eye fundus. One is a widely used modality consisting of a color photograph of the human retina and the other consists of a functional imaging modality that assesses, in vivo, the human blood-retinal barrier function. The need for the nonrigid registration of these two modalities is demonstrated and is due to the acquisition mode of the functional modality. The two modalities here with registered are from two different devices, have different resolutions and different fields-of-view, i.e., the smaller is only a subset of the larger one. In this paper, all these problems were addressed and a solution proposed.