Title :
Molecular imaging of cancer cells using plasmon-resonant-enhanced third-harmonic-generation microscopy with silver nanoparticles
Author :
Tai, Shih-Peng ; Chu, Shi-Wei ; Tsai, Tsung-Han ; Chen, Szu-Yu ; Shi, Xuan-Yu ; Chang, Chien-Huei ; Wu, Yana ; Shieh, Dar-Bin ; Chen, Lung-Jin ; Prasad, Muppa Ramakrishna ; Lin, Kuan-Jiuh ; Sun, Chi-Kuang
Author_Institution :
Graduate Inst. of Electro-Opt. Eng., Nat. Taiwan Univ., Taiwan
Abstract :
We demonstrate molecular-specific third-harmonic-generation microscopy in cultured oral squamous cell carcinoma lines by using silver nano-particles as contrast agent. Through surface plasmon resonance enhancement, cancer cells are clearly identified with their molecular signature.
Keywords :
biomedical optical imaging; cancer; cellular biophysics; molecular biophysics; nanoparticles; optical harmonic generation; optical microscopy; silver; surface plasmon resonance; tumours; Ag; cancer cell imaging; contrast agent; cultured oral squamous cell carcinoma; molecular imaging; molecular signature; molecular-specific third-harmonic-generation microscopy; plasmon-resonant-enhanced third-harmonic-generation microscopy; silver nanoparticles; surface plasmon resonance enhancement; Biomedical optical imaging; Cancer; Molecular imaging; Nanoparticles; Nonlinear optics; Optical imaging; Optical microscopy; Plasmons; Resonance; Silver;
Conference_Titel :
Lasers and Electro-Optics, 2005. (CLEO). Conference on
Print_ISBN :
1-55752-795-4
DOI :
10.1109/CLEO.2005.202179
