Development of a fully rotational non-contact fluorescence tomographer for small animals

Author

Schulz, Ralf B. ; Echner, Gernot ; Rühle, Heinrich ; Stroh, Wolfram ; Vierling, Jurgen ; Vogt, Thomas ; Peter, Jörg ; Semmler, Wolfhard

Author_Institution

German Cancer Res. Center, Heidelberg, Germany

Volume

4

fYear

2005

fDate

23-29 Oct. 2005

Firstpage

2391

Lastpage

2393

Abstract

We present herein the development of a fully 360° rotatable fluorescence tomography system for small animals without the use of source and detector fibers, or optically matching fluids. The setup consists of a cooled CCD camera coupled to a wide-angle objective and an axially moveable, collimated laser source integrated within a rotating light-tight chamber. The system´s capability to acquire and reconstruct high density datasets is demonstrated with experimental results from phantoms.

Keywords

biomedical optical imaging; fluorescence; image reconstruction; laser applications in medicine; medical image processing; optical tomography; phantoms; axially moveable collimated laser source; cooled CCD; fluorescence tomography system; fully rotational noncontact fluorescence tomographer; high density dataset reconstruction; phantoms; rotating light-tight chamber; small animal imaging; wide-angle objective; Animals; Charge coupled devices; Charge-coupled image sensors; Fiber lasers; Fluorescence; Optical collimators; Optical coupling; Optical detectors; Optical fibers; Tomography;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2005 IEEE

ISSN

1095-7863

Print_ISBN

0-7803-9221-3

Type

conf

DOI

10.1109/NSSMIC.2005.1596814

Filename

1596814