DocumentCode
458848
Title
Protein 3D HP model folding simulation based on ACO
Author
Song, Jie ; Cheng, Jiaxing ; Zheng, Tingting
Author_Institution
Key Lab. of Intelligent Comput. & Signal Process., Anhui Univ., Hefei
Volume
1
fYear
2006
fDate
16-18 Oct. 2006
Firstpage
410
Lastpage
415
Abstract
The paper presents an approach to optimize the protein 3D HP model conformation with ant colony optimisation (ACO). A rapid coordinate system transfer matrix according to the "right hand" rule we defined is used to reduce the computing time. A new scheme to solve the problem of folding deadlock is suggested. During the update of pheromone, a new update method with dynamic pheromone is given and three local search methods are provided. Using these methods, 3D conformation of standard test sequences with very low energy was found
Keywords
biophysics; optimisation; proteins; search problems; ant colony optimisation; coordinate system transfer matrix; dynamic pheromone; local search method; protein 3D HP model folding simulation; Amino acids; Ant colony optimization; Biomedical signal processing; Bonding; Computational modeling; Computer science education; Computer simulation; Laboratories; Lattices; Proteins;
fLanguage
English
Publisher
ieee
Conference_Titel
Intelligent Systems Design and Applications, 2006. ISDA '06. Sixth International Conference on
Conference_Location
Jinan
Print_ISBN
0-7695-2528-8
Type
conf
DOI
10.1109/ISDA.2006.221
Filename
4021474
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