Title :
Digital Coincidence Processing for the RatCAP Conscious Rat Brain PET Scanner
Author :
Park, S.-J. ; Southekal, S. ; Purschke, M. ; Junnarkar, S.S. ; Pratte, J.-F. ; Radeka, V. ; Connor, P.O. ; Stoll, S.P. ; Lecomte, R. ; Fontaine, R. ; Woody, C.L. ; Schlyer, D.J. ; Vaska, P.
Author_Institution :
Brookhaven Nat. Lab., NY
fDate :
Oct. 29 2006-Nov. 1 2006
Abstract :
The RatCAP has been designed and constructed to image the awake rat brain. In order to maximize system performance, offline digital coincidence data processing algorithms including offset delay correction and prompt and delayed coincidence detection have been developed and validated. With offset delay correction using a singular value decomposition (SVD) technique, overall time resolution was improved from 32.6 ns to 17.6 ns FWHM. The experimental results confirm that the ratio of prompts (or trues) to randoms was improved because a smaller timing window could be used. 18F-fluoride rat bone scan data was reconstructed with our fully 3-D MLEM with a highly accurate detector response model using Monte Carlo simulation.
Keywords :
brain; medical image processing; positron emission tomography; zoology; 3D MLEM; 18F-fluoride rat bone scan data; Monte Carlo simulation; RatCAP; coincidence detection; conscious rat brain PET scanner; detector response model; digital coincidence processing; maximum-likelihood expectation maximization; offset delay correction; positron emission tomography; singular value decomposition; Animals; Application specific integrated circuits; Data acquisition; Data processing; Delay estimation; Detectors; Positron emission tomography; Singular value decomposition; System performance; Timing; RatCAP; awake rat; offset delay correction; singular value decomposition (SVD);
Conference_Titel :
Nuclear Science Symposium Conference Record, 2006. IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
1-4244-0560-2
Electronic_ISBN :
1095-7863
DOI :
10.1109/NSSMIC.2006.356516
