Title :
Monte Carlo database production for human brain PET imaging using GATE
Author :
Jan, S. ; Comtat, C. ; Trebossen, R.
Author_Institution :
Service Hospitalier Frederic Joliot, Orsay
fDate :
Oct. 29 2006-Nov. 1 2006
Abstract :
This paper presents a set of Gold Standard images where physical effects like positron range, gamma accolinearity and tissue attenuation are note taken into account in the simulation for the 4 functional models and a realistic simulation, including the brain attenuation, for [18F]FluoroDopa tracer. In order to validate this final result in a clinical or pre-clinical situation, we compared a real brain study against our simulation in the field of Parkinson´s disease with an evaluation of striatal uptake constant (Kc) values with a Patlak analysis.
Keywords :
Monte Carlo methods; brain; medical computing; positron emission tomography; GATE simulation tool; Gold Standard images; Monte Carlo database production; Parkinson disease; Patlak analysis; [18F]FluoroDopa tracer; brain attenuation; functional models simulation; gamma accolinearity; human brain PET imaging; positron range; striatal uptake constant; tissue attenuation; Analytical models; Attenuation; Brain modeling; Gold; Humans; Image databases; Monte Carlo methods; Optical imaging; Positron emission tomography; Production;
Conference_Titel :
Nuclear Science Symposium Conference Record, 2006. IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
1-4244-0560-2
Electronic_ISBN :
1095-7863
DOI :
10.1109/NSSMIC.2006.356545
