Monte Carlo database production for human brain PET imaging using GATE

Author

Jan, S. ; Comtat, C. ; Trebossen, R.

Author_Institution

Service Hospitalier Frederic Joliot, Orsay

Volume

5

fYear

2006

fDate

Oct. 29 2006-Nov. 1 2006

Firstpage

3159

Lastpage

3162

Abstract

This paper presents a set of Gold Standard images where physical effects like positron range, gamma accolinearity and tissue attenuation are note taken into account in the simulation for the 4 functional models and a realistic simulation, including the brain attenuation, for [¹⁸F]FluoroDopa tracer. In order to validate this final result in a clinical or pre-clinical situation, we compared a real brain study against our simulation in the field of Parkinson´s disease with an evaluation of striatal uptake constant (Kc) values with a Patlak analysis.

Keywords

Monte Carlo methods; brain; medical computing; positron emission tomography; GATE simulation tool; Gold Standard images; Monte Carlo database production; Parkinson disease; Patlak analysis; [¹⁸F]FluoroDopa tracer; brain attenuation; functional models simulation; gamma accolinearity; human brain PET imaging; positron range; striatal uptake constant; tissue attenuation; Analytical models; Attenuation; Brain modeling; Gold; Humans; Image databases; Monte Carlo methods; Optical imaging; Positron emission tomography; Production;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2006. IEEE

Conference_Location

San Diego, CA

ISSN

1095-7863

Print_ISBN

1-4244-0560-2

Electronic_ISBN

1095-7863

Type

conf

DOI

10.1109/NSSMIC.2006.356545

Filename

4179702