Title :
A Bayesian Neural Network for Competing Risks Models with Covariates
Author :
Arsene, C.T.C. ; Lisboa, P.J.G. ; Boracchi, P. ; Biganzoli, E. ; Aung, M.S.H.
Author_Institution :
School of Computing and Mathematical Sciences, Liverpool John Moores University, Liverpool, United Kingdom. c.arsene@ljmu.ac.uk
Abstract :
This paper presents a Bayesian Neural Network for the analysis of Competing Risk (CR) data model. Based on a previously developed non-linear model namely Partial Logistic Artificial Neural Network (PLANN) with Automatic Relevance Determination (ARD), this paper proposes an extension for the flexible joint estimation of cause-specific hazards depending on both discrete and continuous covariates (PLANN-CR-ARD) and for censored data. The Bayesia analysis uses Gaussian priors for the neural network parameters and the likelihood function based on the competing risk data is identified as the cross-entropy function. The PLANN-CR-ARD model is illustrated with analyses of an Intra-Ocular Melanoma dataset and comparison with the non-parametric Nelson-Allen estimates of the cause-specific cumulative hazards functions.
Keywords :
Bayesian Neural Network; Competing Risks; PLANN-CR-ARD; Survival Analysis;
Conference_Titel :
Advances in Medical, Signal and Information Processing, 2006. MEDSIP 2006. IET 3rd International Conference On
Conference_Location :
Glasgow, UK
Print_ISBN :
978-0-86341-658-3